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Semantics
Semantics is the linguistic and philosophical study of meaning, in language, programming languages, formal logics, and semiotics. It is concerned with the relationship between...-
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Data Interoperability (Surveillance)
The process of assuring interoperability of data is focused on making sure that data can be processed by different systems. Differently from data standardisation, there is no...-
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Variant detection
NGS is frequently used to identify mutations in DNA samples from individual patients or experimental organisms. Sequencing can be done at the whole-genome scale; RNA-seq, which...-
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Consensus Sequence
When two or more DNA sequences are aligned, the overlapping portions can be combined to create a single consensus sequence. In positions where all overlapping sequences have the...-
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Shared Definition
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Sensitivity
sensitivity is the probability that a test correctly classifies positive individuals who have preclinical disease. Sensivity is expressed as a percentage: The number of...-
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Bias
The extent to which a prevalence estimate produced by the surveillance system deviates from the value of the true prevalence . Bias is reduced as representativeness is increased.-
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Structural Interoperability
Structural interoperability is an intermediate level that defines the structure or format of data exchange (i.e., the message format standards) where there is uniform movement...-
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Dendrogram
A branching chart that indicates the evolutionary lineage or genetic relatedness of organisms-
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Data Pseudomysation
The processing of personal data in such a way that the data can no longer be attributed to a specific data subject without the use of additional information, as long as such...-
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Data Standard
Data standards are documented agreements on representation, format, definition, structuring, tagging, transmission, manipulation, use, and management of data.-
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Data completeness and correctness
The proportion of data that were intended to be collected that actually was collected and the proportion of data entries that correctly reflect the true value of the data...-
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Metadata Standard
A metadata standard is a requirement which is intended to establish a common understanding of the meaning or semantics of the data, to ensure correct and proper use and...-
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Controlled Vocabulary
A collection of clearly defined, mutually exclusive, and exhaustive terms, which are the only choices for usage in a specific surveillance context. Compared to ontologies (see...-
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Cost
The evaluation should list and quantify each of the resources required to operate the surveillance system and identify who provides eachresource. These resources could include:...-
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Sequence fragment
A short string of text that represents a portion of a DNA (or RNA) sequence. NGS machines produce short reads that are sequence fragments that are read from DNA fragments.-
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Sequence variants
Differences at specific positions between two aligned sequences. Variants include single-nucleotide polymorphisms (SNPs), insertions and deletions, copy number variants, and...-
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Mathematical Modelling
A mathematical model is an abstract model that uses mathematical language to describe the behaviour of a system.Mathematical models are used particularly in the natural sciences...-
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Uncertainty Analysis
A method used to estimate the uncertainty associated with model inputs, assumptions and structure/form.-
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